Another great example of MIRA powering nextโgen CRISPR diagnostics. ๐งฌ
The CLUE platform decouples crRNA functions to make Cas12a tuning far more flexible โ and with MIRA isothermal amplification behind it, detection wraps up in just 20 minutes.
100% sensitivity and specificity across 120 clinical samples. That's the kind of data that makes you proud of the tech you work with. ๐
| ๐ฌ A new breakthrough in CRISPR diagnostics โ powered by MIRA.
Traditional CRISPR diagnostics tightly couple crRNA target recognition and cleavage activity. Researchers must redesign crRNA sequences for rate matching โ a constrained, trialโandโerror process.
This work introduces the CLUE platform โ decoupling crRNA functions using RNA oligos for independent tuning of Cas12a cisโcleavage.
Powered by MIRA isothermal amplification:
โก Selfโinitiated reactions via strand displacement
โฑ๏ธ Detection completed in just 20 minutes
๐ฏ 100% sensitivity and specificity for SARSโCoVโ2 and influenza across 120 clinical samples โ matching RTโqPCR
๐งฌ A highly customizable universal solution for POCT
This is what happens when MIRA meets smarter CRISPR design โ faster, simpler, and more flexible than ever.
|
The CLUE platform decouples crRNA functions to make Cas12a tuning far more flexible โ and with MIRA isothermal amplification behind it, detection wraps up in just 20 minutes.
100% sensitivity and specificity across 120 clinical samples. That's the kind of data that makes you proud of the tech you work with. ๐
Traditional CRISPR diagnostics tightly couple crRNA target recognition and cleavage activity. Researchers must redesign crRNA sequences for rate matching โ a constrained, trialโandโerror process.
This work introduces the CLUE platform โ decoupling crRNA functions using RNA oligos for independent tuning of Cas12a cisโcleavage.
Powered by MIRA isothermal amplification:
โก Selfโinitiated reactions via strand displacement
โฑ๏ธ Detection completed in just 20 minutes
๐ฏ 100% sensitivity and specificity for SARSโCoVโ2 and influenza across 120 clinical samples โ matching RTโqPCR
๐งฌ A highly customizable universal solution for POCT
This is what happens when MIRA meets smarter CRISPR design โ faster, simpler, and more flexible than ever.