Astrea Bioseparations_Chromatography Resins
Astrea Bioseparations_Chromatography Resins

Mimetic Blue® Affinity Adsorbents for Purification of Albumin & Albumin Related Proteins

2020-07-15
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What is Albumin?

Serum albumin is the most abundant blood plasma protein and is produced in the liver. In human plasma, human serum albumin normally constitutes about 50% of the total protein.

What does Albumin do?

Serum albumins are important in regulating blood volume by maintaining the oncotic pressure (also known as colloid osmotic pressure) of the blood compartment. They also serve as carriers for molecules of low water solubility, this way isolating their hydrophobic nature, including lipid-soluble hormones, bile salts, unconjugated bilirubin, free fatty acids (apoprotein), calcium, ions (transferrin), and some drugs like warfarin, phenobutazone, clofibrate & phenytoin. For this reason, it is sometimes referred as a molecular “taxi”. Competition between drugs for albumin binding sites may cause drug interaction by increasing the free fraction of one of the drugs, thereby affecting potency.

Mimetic Blue®

Astrea Bioseparations’ range of Mimetic Blue® affinity adsorbents comprise Mimetic Blue® ligands attached to beaded agarose supports, which selectively bind to Albumin and Albumin related proteins from a variety of sources, including plasma, serum and recombinant cell cultures to yield highly purified biological products.

The adsorbents are used commercially for the purification of albumin and albumin related proteins (i.e. albumin fusion proteins) but also are applicable to a variety of other proteins including adenine nucleotide binding proteins.

Key features of Mimetic Blue®:

  • High Specificity for albumin and albumin related proteins
  • High dynamic binding capacity (>30mg/ml)
  • Excellent flow properties
  • Robust, long-life adsorbent
  • Sanitizable with NaOH allowing multiple cycles
  • High purity, chemically defined ligand structures
  • Highly reproducible batch-to-batch manufacture to ISO9001 standards
  • Supported with comprehensive Regulatory Support Files
  • Multiple end users in biopharmaceutical manufacture
  • Highly sensitive ELISA assay for leachate analysis and column verification

Mimetic Blue 1 P6XL


Mimetic Blue SA HL P6XL

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Mimetic Blue SA P6XL

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Mimetic Blue SA P6HF

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Mimetic Blue® 1 P6XL affinity chromatography adsorbent is developed and manufactured exclusively by Astrea Bioseparations Ltd (Astrea). It comprises Mimetic Blue® ligand covalently attached to a near monodisperse 6% cross-linked agarose bead (PuraBead® 6XL) and is immobilised using a defined and highly stable spacer-arm linkage which promotes optimal interaction with the target protein.

Mimetic Blue adsorbents can be used for the purification of Albumin, Albumin Fusion Proteins and related proteins from a variety of feedstocks including Plasma, Serum and recombinant cell cultures.

Mimetic Blue® SA HL (“high ligand”) P6XL affinity chromatography adsorbent is developed and manufactured exclusively by Astrea Bioseparations Ltd (Astrea). It comprises Mimetic Blue® ligand covalently attached to a near monodisperse 6% crosslinked agarose bead (PuraBead® 6XL) and is immobilised using a defined and highly stable spacer-arm linkage which promotes optimal interaction with the target protein.

Mimetic Blue adsorbents can be used for the purification of Albumin, Albumin Fusion Proteins and related proteins from a variety of feedstocks including Plasma, Serum and recombinant cell cultures.


Mimetic Blue® SA P6XL affinity chromatography adsorbent is developed and manufactured exclusively by Astrea Bioseparations Ltd (Astrea). It comprises Mimetic Blue® ligand covalently attached to a near monodisperse 6% cross-linked agarose bead (PuraBead® 6XL) and is immobilised using a defined and highly stable spacer-arm linkage which promotes optimal interaction with the target protein.

Mimetic Blue adsorbents can be used for the purification of Albumin, Albumin Fusion Proteins and related proteins from a variety of feedstocks including Plasma, Serum and recombinant cell cultures.


Mimetic Blue® SA P6HF affinity chromatography adsorbent is developed and manufactured exclusively by Astrea Bioseparations Ltd (Astrea). It comprises Mimetic Blue® ligand covalently attached to a near monodisperse 6% cross-linked agarose bead (PuraBead® 6HF) and is immobilised using a defined and highly stable spacer-arm linkage which promotes optimal interaction with the target protein.

Mimetic Blue adsorbents can be used for the purification of Albumin, Albumin Fusion Proteins and related proteins from a variety of feedstocks including Plasma, Serum and recombinant cell cultures.


>25 mg HAS/ml
Up to 60 mg HSA/mL
Up to 30 mg HSA/mL
Up to 30 mg HSA/mL

25 mL
25 mL
25 mL
25 mL
100 mL
100 mL
100 mL
100 mL
500 mL
500 mL
500 mL
500 mL
1000 mL
1000 mL
1000 mL
1000 mL